MK-2682

Description: Methylester Kyseliny-anthranilove is an aryl hydrocarbon which modulates the androgen receptor. Liquid SARM
Concentration: 50mg per ml
Substantively: 24 hours
Organoleptic: Fruit initiation through to mint finish
Use: SARM and Anti-androgen; pushes androgen receptor activity to anabolic activity.
Active Ingredients: Methylester Kyseliny-anthranilove 50mg per ml
Application: 1ml daily with food in the morning.
Ingredients: Propylene Glycol, Methylester Kyseliny-anthranilove and flavour.
Elimination: Anthranilate esters have an average of 7-hour half-lives. Metabolised in liver.
Legal Status: Legal in Australia, food additive, FEMA

MK2682 is a non-steroidal compound designed to prevent muscle wasting, promote muscle growth and increase muscle and bone strength. After binding to receptors, MK2682 increases protein synthesis and anabolic activity, resulting in muscle hypertrophy and healing, mimicking the action of testosterone on muscles and joints. Unlike traditional androgenic steroids MK2682 does not lead to any of the associated side effects such as suppression of testosterone or increase in estrogen, making MK2682 desirable for this reason. Having anti-catabolic action’s, it prevents muscle wastage enabling the individual to hold lean muscle that is gained while trying to drop body fat. 

Key points:

• INCREASED STRENGTH
• INCREASE LEAN MUSCLE GAIN
• INCREASED BONE DENSITY
• INCREASED RECOVERY AND HEALING

Research Evidence & Efficacy

Roell, D., Rösler, T. W., Degen, S., Matusch, R., & Baniahmad, A. (2011). Antiandrogenic activity of anthranilic acid ester derivatives as novel lead structures to inhibit prostate cancer cell proliferation. Chemical biology & drug design, 77(6), 450-459.
2 Negro-Vilar, A. (1999). Selective androgen receptor modulators (SARMs): a novel approach to androgen therapy for the new millennium. The Journal of Clinical Endocrinology & Metabolism, 84(10), 3459-3462.
3 Yin, D., Gao, W., Kearbey, J. D., Xu, H., Chung, K., He, Y., ... & Dalton, J. T. (2003). Pharmacodynamics of selective androgen receptor modulators. Journal of Pharmacology and Experimental Therapeutics, 304(3), 1334-1340.
4 https://tga-search.clients.funnelback.com/s/search.html?query=&collection=tga-artg
5 Gill, A. (2017). Standard for the uniform scheduling of medicines and poisons: The Poisons Standard 2017. Australian Government–Department of health and aging: Therapeutic Goods Administration, Canberra.

Research Evidence & Efficacy

6 Nickols, N. G., & Dervan, P. B. (2007). Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide. Proceedings of the National Academy of Sciences, 104(25), 10418-10423.
7 Masiello, D., Cheng, S., Bubley, G. J., Lu, M. L., & Balk, S. P. (2002). Bicalutamide functions as an androgen receptor antagonist by assembly of a transcriptionally inactive receptor. Journal of Biological Chemistry, 277(29), 26321-26326.
8 Sieber, P. R., Keiller, D. L., Kahnoski, R. J., Gallo, J., & Mcfadden, S. (2004). Bicalutamide 150 mg maintains bone mineral density during monotherapy for localized or locally advanced prostate cancer. The Journal of urology, 171(6), 2272-2276.
9 Schellhammer, P. F. (2002). An evaluation of bicalutamide in the treatment of prostate cancer. Expert opinion on pharmacotherapy, 3(9), 1313-1328.
10 Roell, D., Rösler, T. W., Degen, S., Matusch, R., & Baniahmad, A. (2011). Antiandrogenic activity of anthranilic acid ester derivatives as novel lead structures to inhibit prostate cancer cell proliferation. Chemical biology & drug design, 77(6), 450-459.

CHEQUE BLOK

Type of Terpene: Bicyclic monoterpene
CAS: 13466-78-9
FEMA Number: 3821
JECFA Number: 1342
Formula: C10 H16
Molecular Mass: 136.24g/mol
Legal Status: Legal, FSANZ 1.3.1 & 1.4.4

What is Delta 3 Carene?

Delta 3 carene is a tepene that is commonly found in plants such as cannabis, basil, rosemary and cedar. Terpenes such as delta 3 Carene are organic hydrocarbons that give the plant its flavour and aroma profile as well working to deter herbivores and attract pollinators. They can also have the ability increase cellular permeability and therefore a rapid absorption of cannabinoids.1

What does Delta 3 Carene do?

Delta 3 Carene has been looked at in research for its effectiveness in increasing bone density and promoting bone healing. Delta 3 Carene was shown to stimulate signifcantly the activity and expression of alkaline phosphotase an early phase marker of osteoblastic differentiation. On day 15 of differentiation it dramatically increased the induction of calcium in a dose dependent manner. The increase in bone healing and density may be attributed to the activation of mitogen activated protein kinases and the transcript levels of osteoblast mineralization related genes such as osteopontin and type 1 collagen1.

Other than its bone healing properties delta 3 Carene has shown to have the ability to draw out fluids. This effect makes delta 3 carene potentially useful as an antihistamine to target excess mucus production.

Key points:

• INCREASED BONE DENSITY AND REPAIR
• INCREASE MENTAL FOCUS AND CONCENTRATION
• ANTIHISTAMINE
• ANABOLIC

Research Evidence and Efficacy.

1 Gertsch J, Pertwee RG, Di Marzo V. Phytocannabinoids beyond the Cannabis plant – do they exist? Br J Pharmacol. 2010; 160:523–9. doi: 10.1111/j.1476-5381.2010.00745. x.
2.Jong-Geun Jeong, Young Sup Kim, Yong Ki Min, Seong Hwan Kim. Low concentration of 3-carene stimulates the differentiation of mouse osteoblastic MC3T3-E1 subclone 4 cells(2007) Phytotherapy Research Volume 22, Issue 1
3Cavaleiro, C.Pinto, E. Goncalves, M.J. Salgueiro, L. Antifungal activity of Juniperus essential oils against dermatophyte, Aspergillus and Candida strains (2006) Volume 100, Issue 6, p1333-1338