Item Code: MYOSTIM30ML
Minimum : 1
Maximum : 0
Description: Dihydrocoumarin is a pseudo steroid, which like anabolic steroids and sex hormones, has been shown to upregulate androgen receptor expression. Dihydrocoumarin is a SIRT1 inhibitor pushing cells to differentiate and replicate. Indirect acting liquid SARM 50mg per ml.
Substantively: 24 hours
Organoleptic: Sweat, vanilla and caramel flavour
Use: SARM and Anti-androgen (Pro-anabolic); pushes androgen receptor activity to anabolic activity.
Active Ingredients: Solubilised Dihydrocoumarin androgen receptor ligand 50mg per ml.
Application: 1ml daily with food in the morning in protein shake (250ml liquid).
Ingredients: Vegetable glycerin, Dihydrocoumarin, and Flavour.
Elimination: Two days.
Legal Status: Legal in Australia, food additive FEMA.
• Food Approved
• Promotes fullness and hardness
• Clinical evidence of activity
• Long acting (blood plasma 1.5hrs, tissue 43 hours)
Myostatin is the hormone which balances any negative effects of growth hormone and encourages hypertrophy (size of skeletal muscle cells) at the expense of hyperplasia (number of skeletal muscle cells).
The goal of weight training and supplementation is to safely increase endogenous follistatin and allow it to influence myostatin rather than employ a clinical or research myostatin inhibitor. Research suggests that myostatin inhibitors currently undergoing research would likely lead to coronary disease. The negative effects of complete myostatin inhibition can be seen in the Belgian Blue, a breed of bovine with no working copy of the gene for myostatin. However 97.3% of the cattle are born sterile and 10% die of coronary failure prior to 12 months of age demonstrating that dampening, not inhibition is desirable. ,
Follistatin modulation, on the other hand, can influence myostatin expression and achieve realistic results without negative effects on long term health. ,, New research (2014) has identified a specific chemical in Theobroma species. (-)-Epicatechin is similar to other polyphenols however carries the unique ability to up regulate follistatin by 2.5 times and directly down regulate myostatin. ,, Moreover it has also been linked to a lower risk of heart disease. The issue in the past was its low solubility and thus low bioavailability. Androl is a unique solubilised formula allowing a high level of bioavailability.
By modulating myostatin in humans, a reduction in body fat has been demonstrated. Myostatin inhibition thus has two important effects useful in this context. Increased hyperplasia and muscle mass and decreased adipose tissue. This net effect has been defined as literally anti-aging. Barnett et al 8 found that supplementation twice daily with (-)-epicatechin at 50mg led to a 2.5 times increase in follistatin expression within one week. Pro-follistatin 2.5 capsules are 100mg each and also designed to be taken twice daily.
Dihydrocoumarin is a naturally occurring (in this case nature identical) compound found in Sweet Clover (Melilotus officionalis). Research considered whether dihydrocoumarin could inhibit the human NADþ- dependent deacetylase SIRT1 and observed that DHC induced a concentration-dependent inhibition of SIRT1 (IC50 of 208 microM) in an in vitro enzymatic assay. That is loosely equivalent to 2400mg for an 80kg individual however a decrease in SIRT1 deacetylase activity was observed at micromolar doses with observed activity at as low as 1.6 microM (19mg). The microtubule SIRT2 deacetylase was also inhibited with a similar dose dependency. SIRT1 is a repressor of anabolic and androgenic activity and inhibits DHT mediated transcription thus by inhibiting SIRT1 and SIRT2, anabolic activates are promoted. SIRT1 inhibition also upregulates androgen receptor expression.